Start with the pattern, not the plugin list
Ask when the failure happens. Only in wp-admin? During imports? After publishing? Under traffic? When a backup or scheduled task runs? A repeatable pattern narrows the search much faster than disabling random plugins.
Check the hosting limits
Memory, PHP processes, CPU limits, database load and connection limits can all produce the same visible symptom. A site can have plenty of disk space and still run out of the resource that matters for PHP requests.
Look for expensive background work
Backups, imports, image processing, search indexing and scheduled jobs may compete with normal requests. Moving heavy work away from peak usage or changing the way it runs can be more effective than simply increasing limits.
Plugin conflicts are real, but do not guess
Use logs, timings and a safe test environment where possible. If one plugin triggers the problem, the useful question is whether it is faulty, misconfigured or simply exposing a deeper resource limit.
When to ask for help
If the site is commercially important, intermittent failures are already costing time and trust. Website Rescue is designed for exactly this sort of problem: establish the cause, stabilise the site and decide whether the current setup is still worth supporting.
We can look at the real website with you.
If the issue is already affecting your business, send us the URL and what is happening. We will help you work out the most sensible next step.